Atrial Natriuretic Peptide Frameshift Mutation in Familial Atrial Fibrillation
نویسندگان
چکیده
منابع مشابه
Connexin40 nonsense mutation in familial atrial fibrillation.
Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia associated with substantial morbidity and mortality. Genetic variants play important roles in the pathogenesis of AF. However, AF is a genetically heterogeneous disorder, and the genetic determinants in most patients with AF remain to be identified. In this study, the entire coding region of the connexin40 gene, encoding t...
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OBJECTIVES We sought to characterize natriuretic peptide levels in a cohort of rigorously characterized subjects with lone atrial fibrillation (AF). BACKGROUND Atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) are sensitive biomarkers of cardiac contractile dysfunction. Both peptides have been reported to be elevated in cohorts with AF, but previous studies have included su...
متن کاملDepletion of atrial natriuretic peptide during longstanding atrial fibrillation.
This review focuses on the relation between atrial fibrillation (AF) and atrial natriuretic peptide (ANP). ANP is produced by the atria secondary to atrial stretch. By causing atrial stretch, acute AF leads to an increase in plasma ANP concentration, which serves to normalize haemodynamics through natriuresis and vasodilation. However, data have been reported suggesting that prolonged AF, by in...
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Background: Acute respiratory distress (ARD) is a critical respiratory failure due to lung injury of neonates leading to the clinical appearance of poor lung compliance. The aimed of the study was to evaluate the diagnostic values in differentiating respiratory from heart diseases with using of N-terminal pro brain natriuretic peptide (NT-pro BNP) and Atrial natriuretic peptide(ANP) in neonates...
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Background: Natriuretic peptide (NP) is high in atrial fibrillation (AF) and may decrease after cardioversion to sinus rhythm and the levels of atrial NP (ANP) and brain NP (BNP) in different types of AF and whether ANP and BNP have predictive values for relapsed AF have not been determined. Purpose: We aimed to examine the levels of ANP and BNP in AF to determine their roles in different types...
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ژورنال
عنوان ژورنال: New England Journal of Medicine
سال: 2008
ISSN: 0028-4793,1533-4406
DOI: 10.1056/nejmoa0706300